اثر دو داروی مکمل ترکیبی گیاهی بر کیفیت زندگی مرتبط با سلامت در بیماران دیابت نوع 2

نعمت اللهی, شیما; برازجانی, فاطمه; پیشداد, غلامرضا; ذاکرکیش, مهرنوش; نامجویان, فروغ; احمدی انگالی, کامبیز

doi:10.22055/psy.2022.40703.2841

نوع مقاله : مقاله پژوهشی

نویسندگان

¹ مرکز تحقیقات تغذیه و بیماری‌های متابولیک و پژوهشکده علوم بالینی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران

² گروه آموزشی تغذیه،دانشکده پیراپزشکی،دانشگاه علوم پزشکی جندی شاپور اهواز،اهواز،ایران.

³ مرکز تحقیقات غدد و متابولیسم، دانشگاه علوم پزشکی شیراز، شیراز، ایران

⁴ پژوهشکده سلامت، مرکز تحقیقات دیابت، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران

⁵ گروه فارماکوگنوزی و گروه داروسازی سنتی ایران، دانشکده داروسازی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران

⁶ مرکز تحقیقات عوامل اجتماعی سلامت، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران و گروه آمار و اپیدمیولوژی، دانشکده بهداشت،

https://doi.org/10.22055/psy.2022.40703.2841

چکیده

افزایش شیوع دیابت به دلیل افزایش عادات غذایی ناسالم و سبک زندگی کمتحرک موجب افزایش التهاب و عدم بالانس وضعیت گلایسمی و به دنبال آن سطح کیفیت زندگی کاهش می‌یابد. مطالعه حاضر با هدف بررسی تأثیر مکمل بربرین و شنبلیله در بیماران مبتلا به دیابت نوع 2 طراحی و انجام شد. یک کارآزمایی بالینی تصادفی کنترل‌شده بر روی 50 بیمار مبتلا به دیابت نوع 2 انجام شد. انتخاب شرکت‌کنندگان به‌صورت تصادفی به دو گروه مداخله و دارونما صورت گرفت و گروه مداخله به تعداد 25 نفر که روزانه با دریافت 3 کپسول 500 میلی‌گرمی (300 میلی‌گرم بربرین + 200 میلی‌گرم پودر دانه شنبلیله) و گروه دارونما به تعداد 25 نفر، روزانه 3 کپسول 500 میلی‌گرمی دارونما به مدت 12 هفته دریافت کردند. 17 نفر از هر گروه مورد مطالعه زن و 8 نفر مرد بودند. در ابعاد کیفیت زندگی گروه مداخله افزایش معنی‌داری مشاهده شد و در گروه دارونما در پایان مطالعه فقط در 3 مورد از ابعاد معنی‌دار شد. میانگین نمره خلاصه مؤلفه جسمی (PCS) از ابتدا تا هفته 12 به‌طور قابل توجهی تقریباً در دوگروه مداخله (05/6 ± 26/49) و دارونما (30/5 ± 28/49) مشابه بود. تغییرات میانگین درون گروهی نمره خلاصه مؤلفه ذهنی (MCS) در ابتدای مطالعه در گروه مداخله (001/0=P) بیشتر از گروه دارونما (4/0=P) بود. از ابتدا تا انتهای اجرای پژوهش و مصرف مکمل ترکیبی در دو مؤلفه ارتباط معنی‌‌داری یافت نشد. ترکیب مکمل بربرین و دانه شنبلیله می‌تواند منجر به بهبود کیفیت زندگی بیماران دیابتی شده و در نتیجه میتوان از نقش ضد دیابتی و ضد التهابی آن حمایت کرد.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Two Combined Herbal Supplements on Health-related Quality of Life in Type2 Diabetes Patients

نویسندگان [English]

Shima Nematollahi ¹
Fatemeh Borazjan ²
Gholam Reza Pishdad ³
Mehrnoosh Zakerkish ⁴
Foroogh Namjoyan ⁵
Kambiz Ahmadi Angali ⁶

¹ Nutrition and Metabolic Diseases Research Center and Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

² department of nutrition, faculty of allied sciences, jundishapur university of medical sciences,ahvaz,,ahvaz iran

³ Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

⁴ Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

⁵ Department of Pharmacognosy and Department of Traditional Pharmacy of Iran, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

⁶ Health Social Factors Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran and Department of Statistics and Epidemiology, Faculty of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

چکیده [English]

Introduction
Increased prevalence of diabetes due to increased unhealthy eating habits, and a sedentary lifestyle increases inflammation and imbalance of glycemic status and consequently decreases the quality of life.

Method
A randomized controlled clinical trial was performed on 50 patients with type 2 diabetes. Participants in the intervention group who received 3 capsules of 500 mg (300 mg of berberine + 200 mg of fenugreek seed powder) or a placebo daily for 12 weeks were randomly selected.

Results
68% of each study group was female. Most dimensions of quality of life were significantly increased in the intervention group and the placebo group at the end of the study was significant in only 3 of the dimensions. The mean physical component summary score (PCS) from baseline to week 12 was significantly approximately similar in the intervention and placebo groups. In contrast, the mean changes within the group's mental component summary score (MCS) at the beginning of the study in the intervention group (P = 0.001) were greater than the placebo group (P = 0.4). While no significant relationship was observed between the two groups at the beginning and end of the intervention.

Discussion
The current study assessed for the first time the combined effect of berberine and fenugreek seed on glycemic indices, inflammatory factors, lipid profiles health-related quality of life in T2DM patients. One of the main reasons for the difference in the results of this study and the lack of significant effect following supplementation with berberine and fenugreek on various factors, unlike the results of previous studies, was related to the dose used. We used the lower dose of these two plants with the aim of better gastrointestinal tolerance, and it seems that this dose does not have a significant effect on some biochemical factors. Diabetes obviously could affect both the health and quality of life of patients. Likewise, type 2 diabetes patients have a lower quality of life than those healthy persons. Accordingly, health-related quality of life would be assessed through several domains including physical and psychological health. In the current study, the SF-12 subscale in the intervention group significantly improved scores for general health (GH), vitality (VT), mental health (MH), physical functioning (PH), Role physical (RP), social functioning (SF), role emotional (RE), physical component summary (PCS) score and also increased the mental component summary (MCS) score. Similarly, in other clinical studies, intervention with herbal medicine, date, and synbiotics augmented the quality of life scores for some of the subscales. The finding of a recent Meta-analysis showed physiological or clinical outcomes, and westernize diet was associated with the QOL of type 2 diabetes patients. The combination of berberine and fenugreek seeds can improve the quality of life in diabetic patients by improving their metabolic status, so it can support the anti-diabetic and anti-inflammatory role of berberine and fenugreek seeds.

کلیدواژه‌ها [English]

Berberine
Fenugreek
Glycemic status
Quality of life
Type 2 diabetes

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دست‌آوردهای روان‌شناختی

اثر دو داروی مکمل ترکیبی گیاهی بر کیفیت زندگی مرتبط با سلامت در بیماران دیابت نوع 2

مراجع

مراجع

دوره 30، شماره 1 - شماره پیاپی 29
فروردین 1402
صفحه 1-18

اثر دو داروی مکمل ترکیبی گیاهی بر کیفیت زندگی مرتبط با سلامت در بیماران دیابت نوع 2

مراجع

مراجع

دوره 30، شماره 1 - شماره پیاپی 29فروردین 1402صفحه 1-18

دوره 30، شماره 1 - شماره پیاپی 29
فروردین 1402
صفحه 1-18