This study was carried out to identify the major factors of acadmic uropout of high school male students in the city of Ahvaz, Iran. The sample consisted of 400 male students who were selected randomly from grades I to 4 of the three majors of mathematics, sciences, and humanities. The factors of academic dropout were identified by the statistical method of factor analysis. The hypotheses tested in this study claimed that the dropout factors have simple and multiple correlations with the number of permanent and temporary academic failures of the subjects. Two measures were used to collect the required data: a questionnaire containing 97 items concerning the academic dropout, and a measure to determine the number of students’ temporary and permanent academic failures at different grade levels. The factor analysis provided the following 10 factors: 1. curriculum problems, 2. family- health problems, 3. environmental- school problems, 4. social- behavioral problems, 5. growth problems, 6. examination problems, 7. textbook problems, 8. educational problems, 9. general problems, and 10. family conflicts. The results revealed that the four factors of carriculum, examination, textbooks, and educational problems had significant simple correlations with the number of students’ permanent failures. On the other hand, the stepwise multiple regression showed that only factor 6, i.e., examination problems, had an orthogonal relationship with the number of students’ permanent failures. The five factors of family- health, environmental school, educational, general problems, and family conflicts had significant simple correlations with the number of students’ temporory failures, while, the four factors of family- health, general, educational, and environmental- school problems had a multiple correlation with the number of students’ tempovary failures.